Naslov
Synthesis of heterocyclic compounds with biological activity in deep eutectic solvents

Autori
Komar, Mario ; Molnar, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1st Young Scientist Day – PhD Conference – Book of Abstracts / Jokić, Stela ; Kovač, Tihomir - Osijek, 2018, 18-18

Skup
1st Young Scientist Day - PhD conference

Mjesto i datum
Osijek, Hrvatska, 14.06.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
deep eutectic solvents, Knoevenagel condensation, rhodanine, quinazolinone

Sažetak
Deep eutectic solvents(DESs)are novel generation of green solvents which have proven to be a convenient media for many synthetic routes. They are often characterized as environmentally friendly and sustainable mixtures of nontoxic and cheap components which are combined together from a eutectic mixture. Hydrogen bond acceptors (HBAs ; quaternary ammonium or metal salt) are often combined with hydrogen bond donors (HBDs ; amides, carboxylic acids, alcohols and sugars) in different ratios to obtain DES with desirable physical and chemical characteristics. Hereby, we describe our achievements in the field of heterocycle synthesis in DESs. So far, we have found DESs to be very effective in synthesis of novel coumarinyl Schiff bases, Knoevenagel condensation of rhodanine with aromatic aldehydes, synthesis of thiosemicarbazides and triazoles from isothiocyanates and coumarinyl hydrazide, synthesis of 2-mercaptoquinazolinones from anthranilic acid and isothiocyanates. At present, a screening of 20 different deep eutectic solvents has been carried out to determine a convenient DES and temperature for the synthesis of quinazoline derivatives from anthranilic or substituted anthranilic acid.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA