Naslov
Surface Modification of Silicone with Colloidal Polysaccharides Formulations for the Development of Antimicrobial Urethral Catheters

Autori
Bračič, Matej ; Šauperl, Olivera ; Strnad, Simona ; Plohl, Olivia ; Kosalec, Ivan ; Fras Zemljič, Lidija

Izvornik
Applied surface science (0169-4332) 463 (2019); 889-899

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
silicone ; catheters ; polysaccharides ; coating ; antifouling ; antibacterial

Sažetak
In this work, surfaces of casted silicone sheets and silicone tubes were functionalized with colloidal polysaccharide complexes (chitosan, carboxymethyl chitosan, and hyaluronic acid in combination with a lysine- based surfactant) in order to introduce antimicrobial and antifouling surface properties. The surface chemistry and morphology, as well as the chemical and mechanical stability of the coatings were characterized. For this purpose, different microscopic and spectroscopic methods, pH- potentiometric titrations and standard methods for evaluation of mechanical properties were used. Finally, the antimicrobial and antifouling properties of functionalized silicone materials were evaluated in vitro. The findings of the physicochemical characterization showed that a discontinuous 3- step dip-coating process can be successfully implemented to coat casted polydimethylsiloxane sheets with colloidal polysaccharide complexes. These coatings exhibit slow-release leaching in aqueous environment at pH 4.5, 7, and 8 and show very good stability against mechanical abrasion, thus displaying high stability potential during catheter insertion. The antimicrobial properties against gram-positive bacteria, gram-negative bacteria and fungi, showed inhibition of bacterial growth of up to 86 %. Furthermore, the bacterial biofilm formation tests have revealed that the hyaluronic acid-surfactant coating exhibits high biofilm growth reduction.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Farmacija

POVEZANOST RADA