Naslov
Mechanism of action of newly synthetized N-9-sulfonylpurine derivatives

Autori
Jukić, Marijana ; Opačak-Bernardi, Teuta ; Matić, Josipa ; Žinić, Biserka ; Glavaš-Obrovac, Ljubica.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1st young scientist day –PhD Conference . book of abstracts / Jokić, Stela ; Kovač, Tihomir - Osijek : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2018, 19-19

ISBN
978-953-7005-53-5

Skup
1st Young Scientist Day - PhD conference

Mjesto i datum
Osijek, Hrvatska, 14.06.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
sulfonylpurine derivatives ; apoptosis ; ROS

Sažetak
Two new N-9-sulfonylpurine derivatives (SPD 1 and SPD12) containing nucleobase and sulfonamide pharmacophores were designed to induce cell death in tumors cells by interacting with cellular molecules and organelles. Flow cytometry was used to determine effect of tested compounds on the cell cycle, apoptosis, mitochondrial potential and accumulation of ROS in treated cells as well. Selected compounds caused accumulation of cells mostly in subG0 phase of cell cycle and induction of apoptosis in almost 55 % of treated cells. Furthermore, SPD1 and SPD12 induced increased accumulation of ROS and mitochondrial disruption in more than 80% of cervical adenocarcinoma (HeLa) and Burkitt lymphoma (Raji) cells. Mechanism of action of selected derivatives is achieved by promotion of apoptosis and accompanied with impaired mitochondrial potential as well as increased ROS accumulation. Purine derivatives with styrylsulfonyl group are good candidates for further investigation of antitumor effects in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA