Naslov
Mathematical Model for Human High Density Lipoprotein Dynamics

Autori
Brnjas-Kraljević, Jasminka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Conference on Biological Physics / Go, Nobuhiro - Kyoto, 2001, 125-125

Skup
4th International Conference on Biological Physics

Mjesto i datum
Kyoto, Japan, 30.07.2001. - 03.08.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HDL; aterogeneza; spinsko označavanje
(HDL; atherogenesis; spin label)

Sažetak
The dynamics of the lipid monolayer was monitored by spin label Tempo incorporated into the lipoprotein via its reduction with ascorbic acid. The reduction of the paramagnetic nitroxide into the nonparamagnetic hydroxylamine form caused the decrease of the ESR signal with time. The experiments clearly demonstrate that the solubilisation of the ambivalent molecule Tempo in the hydrophobic environment of HDL enhanced its reaction kinetics. In order to explain experimental data the model for reduction of Tempo by ascorbic acid is proposed which assumes that the processes taking place in these heterogeneous systems are determined by the overall reaction rate dependent on the local concentrations of the reactants as well as on their transport coefficients for the particular phases. The model was checked by measurements in different concentrations. According to the obtained results we can propose that HDL2 subfraction is more efficient than HDL3 in promoting the reaction what could be related to the difference in atherogenetic protection behavior between these two members of the lipoprotein particles family.

Izvorni jezik
Engleski

Znanstvena područja
Fizika

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