Naslov
SAHAquines regulate metalloproteinases in human glioblastioma

Autori
Zhang, Issan ; Moquin, Alex ; Beus, Maja ; Zorc, Branka ; Maysinger, Dusica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
23rd Annual Pharmacological Research Day / - Montréal : McGill, 2018, P34-P34

Skup
23rd Annual Pharmacological Research Day

Mjesto i datum
Montréal, Kanada, 14.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
hybrid molecule ; glioblastoma ; metalloenzymes

Sažetak
Glioblastoma multiforme is the most common and deadly type of brain tumors. Its metastatic potential relies on high levels of matrix metalloproteinases (MMPs) that degrade the extracellular matrix and basement membranes to promote cancer invasion. Although the role of MMPs in cancer is well established, little is known about the effect of chemotherapeutic drugs on their expression and activity. SAHAquines, novel structural analogs of SAHA and primaquine, are lipophilic weak acids found in lysosomes. Lysosomal exocytosis plays a role in cancer drug resistance. Data from our pilot studies suggest that one of the SAHAquines reduces the viability of A1235 glioblastoma, but its effect on lysosomes and MMPs has not been explored.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA