Naslov
Assessing the mycotoxicological risk from consumption of complementary foods by infants and young children in Nigeria

Autori
Ojuri T., Oluwaseun ; Ezekiel N., Chibundu ; Sulyok, Michael ; Ezeokoli T., Obinna ; Oyedele A., Oluwawapelumi ; Ayeni I., Kolawole ; Eskola K., Mari ; Šarkanj, Bojan ; Hajšlová, Jana ; Adeleke A., Rasheed ; Nwangburuka C., Cyril ; Elliott T., Christopher ; Krska, Rudolf

Izvornik
Food and chemical toxicology (0278-6915) 121 (2018); 37-50

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
child health ; complementary foods ; exposure and risk assessment ; infant nutrition ; mycotoxins ; public health

Sažetak
This study assessed, for the first time, the mycotoxicological risks from consumption of complementary foods by infants and young children in Nigeria. Molds belonging to Aspergillus aculeatinus, A. flavus, A. luchuensis, A. tubingensis, A. welwitschiae and Geotrichum candidum were recovered from the complementary foods. Twenty-eight major mycotoxins and derivatives, and another 109 microbial metabolites including chloramphenicol (a bacterial metabolite), were quantified in 137 food samples by LC-MS/MS. Aflatoxins and fumonisins co-contaminated 42% of the cereal- and nut-based food samples, at mean concentrations exceeding the EU limits of 0.1 and 200 μg/kg set for processed baby foods by 300 and six times, respectively. Milk contained mainly beauvericin, chloramphenicol and zearalenone. The trichothecenes, T-2 and HT-2 toxins, were quantified only in infant formula and at levels three times above the EU indicative level of 15 μg/kg for baby food. Chronic exposure estimate to carcinogenic aflatoxin was high causing low margin of exposure (MOE). Exposures to other mycotoxins either exceeded the established reference values by several fold or revealed low MOEs, pointing to important health risks in this highly vulnerable population. The observed mycotoxin mixtures may further increase risks of adverse health outcomes of exposure ; this warrants urgent advocacy and regulatory interventions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Prehrambena tehnologija, Nutricionizam

Napomena
This work was supported by the European Union's
Horizon 2020 research and innovation programme
(grant agreement No. 692195 (MultiCoop)), and the
National Research Foundation of South Africa
(grant unique numbers 84168 and 98692). The
authors sincerely thank the households that
provided food samples for this study. We
appreciate the assistance of Ihuoma Chibuzor-
Onyema during sampling and the technical
assistance of Iviwe Notununu in molecular aspect
of the study.

POVEZANOST RADA