Naslov
Noninvasive Biomarkers of Asthma

Autori
Mirjana Turkalj, Damir Erceg, Iva Dumbović Dubravčić

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, stručni

Knjiga
Asthma Diagnosis and Menagement

Urednik/ci
Kuan-Hsiang Gary Huang, Chen Hsuan Sherry Tsai

Izdavač
IntechOpen

Grad
London : Delhi

Godina
2018

Raspon stranica
3-19

ISBN
978-1-78923-322-3

Ključne riječi
asthma, biomarker, inlammation, phenotype, endotype

Sažetak
Asthma is a heterogeneous disease of the lower airways including various types of bronchial inlammation presenting with diferent phenotypes and endotypes. Therapeutic response of asthmatic phenotypes/endotypes can be predicted by the use of biomarkers of inlammation phenotyping, and in recent years, endotyping of asthmatics allows to predict who will best respond to anti-inlammatory treatment and optimize quality of life of asthmatics by reducing the risk of exacerbations. Based on noninvasive biomarkers of inlammations, several of them have been described that are useful in clinical practice. Some of the noninvasive biomarkers have a particularly important role in the diagnosis and treatment of asthmatics. Monitoring of noninvasive biomarkers, such as fraction of exhaled nitric oxide (FENO), cells in sputum, or biomarkers in exhaled breath condensate (EBC), two main inlammatory phenotypes have been described: eosinophilic phenotype and neutrophilic phenotype. In eosinophilic asthma, as the most prevalent inlammatory phenotype, asthmatics have more than 3% eosinophils in the sputum, elevated levels of FENO, and elevated leukotriene’s cytokine levels in EBC. The most extensively studied biomarkers in asthma are TH2 or more generally T2-related asthmatic endotype. Their clinical beneit might be used to phenotype/endotype features of the underlying type of inlammation and selection of asthmatics, particularly with severe or diicult-to-treat asthma, which most likely will respond to additional biological therapy. In this chapter, we summarize the noninvasive biomarkers available for the management of asthmatics.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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