Naslov
Određivanje onečišćenja UPLC-MS metodom nastala degradacijom nepafenaka
(Determination of degradation impurities in nepafenac by UPLC-MS)

Autori
Runje, Mislav ; Vojčić, Nina ; Dujmić Vučinić, Željka ; Krizmanić, Irena ; Meštrović, Ernest ; Babić, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Knjiga sažetaka "24. Hrvatski skup kemičara i kemijskih inženjera" / Ukić, Šime ; Bolanča, Tomislav - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2015, 182-182

ISBN
978-953-6894-54-3

Skup
24. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 21.04.2015. - 24.04.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
UPLC-MS, nepafenak
(UPLC-MS, nepafenac)

Sažetak
The degradation studies were performed on Nepafenac active pharmaceutical ingredient in order to qualify potential degradation impurities. Degradation products of Nepafenac formed under different forced conditions have been identified using LC-PDA and LC-MS techniques. Nepafenac was subjected to forced degradation under the conditions of hydrolysis, photolysis, oxidation, dry and wet heat, in accordance with the International Conference on Harmonization. Using ESI product ion scan, mass measurement was performed on the protonated molecular ion, and its result confirms the theoretical elemental composition of unknown impurities: Impurity RRT 0.92 at m/z = 285 [M+H]+, Impurity RRT 1.11 at m/z = 253 [M+H]+ and Impurity RRT 1.78 at m/z = 521 [M+H]+. The degradation pathway of the Nepafenac in acid and based hydrolysis as well as in oxidation is proposed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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