Naslov
White Wine Consumption Influences Inflammatory Phase of Repair After Myocardial Infarction in Rats

Autori
Ključević, Nikola ; Milat, Ana Marija ; Grga, Mia ; Mudnić, Ivana ; Boban, Mladen ; Grković, Ivica

Izvornik
Journal of cardiovascular pharmacology (0160-2446) 70 (2017), 5; 293-299

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
myocardial infarction, white wine, MMP-2, MMP-9, NF-kB, TGF-b

Sažetak
Effects of white wine (WW) consumption on the expression of inflammatory markers/mediators (MMP-2, MMP-9, NF-ĸB p65 and TGF-b1) in myocardial tissue after experimentally induced permanent myocardial ischemia was investigated. Male Sprague-Dawley rats were given either a combination of WW and water or only water, for 28 days. After coronary ligation, animals were left to survive for 24 hours. Three representative areas: infarct/ ischemic, peri- infarct/border zone, and control/non-ischemic zones were analyzed for expression of immunoreactivity by measuring the threshold area % of signal density. For MMP-9, significantly smaller expression was found in all 3 zones of wine drinking animals (P<0.001). There was no difference in MMP-2 immunoreactivity between the 2 groups, except in peri-infarct zones, where the signal was significantly decreased (P<0.001). The same pattern of expression was found for the NF-kB p65 signal, although no differences between experimental groups were observed for TGF-b1. White wine consumption decreases the expression of the 3 investigated inflammatory markers/mediators in the peri- infarct zone, suggesting its significant modulatory effect. For MMP-9 and MMP-2, expression was similar to the effect of postischemic reperfusion. No effect on TGF-b1 was observed, highlighting its role in being the masterswitch, changing from the inflammatory to the proliferative stage of infarct healing.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Nutricionizam, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA