Naslov
Equine melanoma in a population of 296 grey Lipizzaner horses

Autori
Seltenhammer, M.H. ; Simhofer, H. ; Zechner P. ; Curik, Ino ; Solkner, J. ; Brandt, S.M. ; Jansen, B. ; Pehamberger, H. ; Eisenhamer, E.

Izvornik
Equine Veterinary Journal (0425-1644) 35 (2003), 2; 153-157

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
horse; melanoma; heritability;

Sažetak
A clinical study conducted on a defined population of 296 grey horses of Lipizzaner breed revealed dermal melanoma in 148 horses (50 %). 68 of the greys observed were more than 15 years old, 51 of them were melanoma-bearing. In 75.6 % of the cases, melanotic tumours were detected underneath the tail. Individuals were classified according to their stage of disease using a 0 to 5 scale. Although melanoma-bearing grey horses were encountered up to stage 4, it is remarkable that none of the affected individuals showed any severe clinical picture or was handicapped in performance. In contrast to solid coloured horse melanomas characterised by early metastatic development, grey horse melanomas showed less malignancy. Afflicted individuals often exhibited encapsulated nodules or structures similar to human blue nevi. Grey horse-specific genetic factors inhibiting metastatic processes may be responsible for this phenomenon. Statistical analysis revealed highly significant effects of stud and age (P<0.0001) explaining 28 % of the total variability. Heritability was estimated on a sample of 296 grey horses with pedigrees traced back as far as 32 generations and obtained estimate 0.36 with standard error equal to 0.11 indicate that inherited predisposition may be a key factor for melanoma development in grey horses.

Izvorni jezik
Engleski

Znanstvena područja
Poljoprivreda (agronomija), Biotehnologija

POVEZANOST RADA