Naslov
Evaluation of antiproliferative effect of 2, 6, 7-trihydroxy-9-phenyl-3H-xanthene-3-one derivates in vitro

Autori
Harej, Anja ; Klobučar, Marko ; Kraljević Pavelić, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Izvornik
12th Central European Oncology Congress, Croatian Society of Oncology’s Best of ASCO® Conference ; 22-25.06.2015 / - , 2015

Skup
12th Central European Oncology Congress, Croatian Society of Oncology’s Best of ASCO® Conference ; 22-25.06.2015

Mjesto i datum
Opatija, Hrvatska, 22.06.2015. - 25.06.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
xanthen-3-one derivatives, antiproliferative evaluation, antioxidant potency

Sažetak
Ten biologically active xanthen-3-one derivatives were synthesized. Structures of novel compounds were confirmed by IR, 1H, 13C NMR and mass spectrometry. Majority of tested compounds exerted antiproliferative effects at higher tested concentrations (10–100 µM). Compound 9-(4-chlorophenyl)-2, 6, 7-trihydroxyxanthen-3-one (4) exerted the most potent and selective antiproliferative activity in the micromolar range (0.1–10 µM) on all tested cell lines except on SW620 and is thus suitable for further biological evaluation. The strongest effect of compound 4 on HeLa cells was accompained by induction of mitotic catastrophe and apoptotis. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Electrochemical behaviour of studied compounds was compared to the basic non-substituted compound. Shift of the biological oxidation potential towards lower values was obtained for the substituted compounds pointing to the improvement in the reducing power of the compounds.

Izvorni jezik
Engleski

POVEZANOST RADA