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Pregled bibliografske jedinice broj: 946591

Kinetic characterization of enzymes in a multi-enzyme cascade reaction for the synthesis of statin side-chain precursors

Sudar, Martina; Vasić-Rački, Đurđa; Hernandez, Karel; Clapés, Pere; Findrik Blažević, Zvjezdana
Kinetic characterization of enzymes in a multi-enzyme cascade reaction for the synthesis of statin side-chain precursors // European congress of Biotechnology 2018 / Lescai, Francesco ; Rudelsheim, Patrick (ur.).
Ženeva, Švicarska: Elsevier, 2018. str. 63-63 doi:10.1016/j.nbt.2018.05.1076 (poster, međunarodna recenzija, sažetak, znanstveni)

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Naslov
Kinetic characterization of enzymes in a multi-enzyme cascade reaction for the synthesis of statin side-chain precursors

Autori
Sudar, Martina ; Vasić-Rački, Đurđa ; Hernandez, Karel ; Clapés, Pere ; Findrik Blažević, Zvjezdana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European congress of Biotechnology 2018 / Lescai, Francesco ; Rudelsheim, Patrick - : Elsevier, 2018, 63-63

Skup
European Congress on Biotechnology

Mjesto i datum
Ženeva, Švicarska, 01.07.2018. - 04.07.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cascade reaction, kinetic characterization, statin side-chain precursors

Sažetak
Statins are a class of medicine that lower the level of low-density lipoprotein (LDL) cholesterol in blood. This can reduce the risk of cardiovascular disease and prevent heart attack and stroke. The modern requirements for stereochemical purity have created new challenges for industrial preparation of statins. One of the ways to achieve the required enantio- and diastereopurities is the use of biocatalysis. In this work, a cascade reaction with three enzymes was investigated for the synthesis of statin side-chain precursors. The first enzyme in this cascade is alcohol dehydrogenase used for the oxidation of an alcohol to aldehyde. The second enzyme is NADH oxidase used for coenzyme regeneration and the third one is deoxyribose-phosphate aldolase for the aldol addition of acetaldehyde and the corresponding aldehyde. All three enzymes were kinetically characterized in order to develop a mathematical model. Mathematical modeling plays an important part in developing processes involving biocatalysts. In order to reach industrial application, each enzyme and reaction system have to be kinetically characterized. Modelling increases our knowledge about the process, since it enables simulation of different reaction courses. This offers better understanding of the effect that different variables have on the equilibrium, conversion etc.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo, Biotehnologija



POVEZANOST RADA

Projekti:
EK-H2020-635595 - Sustainable industrial processes based on a C-C bond-forming enzyme platform (CARBAZYMES) (Findrik Blažević, Zvjezdana, EK - H2020-LEIT-BIO-2014-1) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Martina Sudar (autor)

Avatar Url Đurđa Vasić-Rački (autor)

Avatar Url Zvjezdana Findrik Blažević (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Sudar, Martina; Vasić-Rački, Đurđa; Hernandez, Karel; Clapés, Pere; Findrik Blažević, Zvjezdana
Kinetic characterization of enzymes in a multi-enzyme cascade reaction for the synthesis of statin side-chain precursors // European congress of Biotechnology 2018 / Lescai, Francesco ; Rudelsheim, Patrick (ur.).
Ženeva, Švicarska: Elsevier, 2018. str. 63-63 doi:10.1016/j.nbt.2018.05.1076 (poster, međunarodna recenzija, sažetak, znanstveni)
Sudar, M., Vasić-Rački, Đ., Hernandez, K., Clapés, P. & Findrik Blažević, Z. (2018) Kinetic characterization of enzymes in a multi-enzyme cascade reaction for the synthesis of statin side-chain precursors. U: Lescai, F. & Rudelsheim, P. (ur.)European congress of Biotechnology 2018 doi:10.1016/j.nbt.2018.05.1076.
@article{article, author = {Sudar, Martina and Vasi\'{c}-Ra\v{c}ki, \DJur\dja and Hernandez, Karel and Clap\'{e}s, Pere and Findrik Bla\v{z}evi\'{c}, Zvjezdana}, year = {2018}, pages = {63-63}, DOI = {10.1016/j.nbt.2018.05.1076}, keywords = {cascade reaction, kinetic characterization, statin side-chain precursors}, doi = {10.1016/j.nbt.2018.05.1076}, title = {Kinetic characterization of enzymes in a multi-enzyme cascade reaction for the synthesis of statin side-chain precursors}, keyword = {cascade reaction, kinetic characterization, statin side-chain precursors}, publisher = {Elsevier}, publisherplace = {\v{Z}eneva, \v{S}vicarska} }
@article{article, author = {Sudar, Martina and Vasi\'{c}-Ra\v{c}ki, \DJur\dja and Hernandez, Karel and Clap\'{e}s, Pere and Findrik Bla\v{z}evi\'{c}, Zvjezdana}, year = {2018}, pages = {63-63}, DOI = {10.1016/j.nbt.2018.05.1076}, keywords = {cascade reaction, kinetic characterization, statin side-chain precursors}, doi = {10.1016/j.nbt.2018.05.1076}, title = {Kinetic characterization of enzymes in a multi-enzyme cascade reaction for the synthesis of statin side-chain precursors}, keyword = {cascade reaction, kinetic characterization, statin side-chain precursors}, publisher = {Elsevier}, publisherplace = {\v{Z}eneva, \v{S}vicarska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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