Trace elements concentrations association with schizophrenia symptoms; a cross-sectional study in Croatia

Todorić Laidlaw, Ivana; Mimica, Ninoslav; Momčilović, Berislav; Jurasović, Jasna; Caratan, Sandra; Filipčić, Igor; Vuk Pisk, Sandra; Bajić, Žarko; Drmić, Stipe

doi:10.24869/psyd.2018.164

Pregled bibliografske jedinice broj: 945496

Trace elements concentrations association with schizophrenia symptoms; a cross-sectional study in Croatia

Todorić Laidlaw, Ivana; Mimica, Ninoslav; Momčilović, Berislav; Jurasović, Jasna; Caratan, Sandra; Filipčić, Igor; Vuk Pisk, Sandra; Bajić, Žarko; Drmić, Stipe

Trace elements concentrations association with schizophrenia symptoms; a cross-sectional study in Croatia // Psychiatria Danubina, 30 (2018), 2; 164-171 doi:10.24869/psyd.2018.164 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 945496 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Trace elements concentrations association with schizophrenia symptoms; a cross-sectional study in Croatia
(Trace elements concentrations association with schizophrenia symptoms; a cross-sectional study in Croatia)

Autori
Todorić Laidlaw, Ivana ; Mimica, Ninoslav ; Momčilović, Berislav ; Jurasović, Jasna ; Caratan, Sandra ; Filipčić, Igor ; Vuk Pisk, Sandra ; Bajić, Žarko ; Drmić, Stipe

Izvornik
Psychiatria Danubina (0353-5053) 30 (2018), 2; 164-171

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
schizophrenia ; bio-elements ; trace elements ; BPRS

Sažetak
Significant inconsistencies exist in findings on association of bio- elements (BE) concentrations and schizophrenia. Hypothesis of this research was that different concentrations of BE are associated with different psychopathological schizophrenia symptoms.This cross- sectional study was performed from 2014 to 2016 at Psychiatric Hospital "Sveti Ivan" and University Psychiatric Hospital "Vrapče", Zagreb, Croatia, on the consecutive sample of 67 patients diagnosed with schizophrenia. BE concentrations were measured by Inductively Coupled Plasma Mass Spectrometry (ICP- MS) at the Institute for Medical Research and Occupational Health in Zagreb. Severity of schizophrenia symptoms was assessed on Brief Psychiatric Rating Scale (BPRS).After adjustment for all preplanned possible confounding variables, the first canonical correlation between BE and BPRS dimensions variates were statistically significant (Rc2=0.73 ; P=0.006). The first pair of canonical variates is defined by BPRS negative dimension (and marginally by positive symptoms and lack of resistance), and copper (Cu), lead (Pb), lithium (Li) and cobalt (Co) (marginally by cadmium (Cd) and nickel (Ni)).Concentrations of different BE are associated with different schizophrenia symptoms. Maximal correlation between BPRS and BE may be achieved with the weighted linear composite of negative schizophrenia symptoms and copper (Cu), lead (Pb), lithium (Li) and cobalt (Co).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinička bolnica "Dubrava",
Medicinski fakultet, Osijek,
Psihijatrijska bolnica "Sveti Ivan" Zagreb,
Institut za istraživanje i razvoj održivih eko sustava

Profili:

Jasna Jurasović (autor)