Naslov
Presence of Helicobacter Pylori in the Stomach and Laryngeal Mucosal Linings in Patients with Laryngeal Cancer.

Autori
Pajić Matić, Ivana ; Jelić, Davor ; Matić, Ivo ; Maslovara, Siniša ; Mendeš, Tihana

Izvornik
Acta clinica Croatica (0353-9466) 57 (2018), 1; 91-95

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Helicobacter Pylori ; Bacterial infections ; Laryngeal neoplasms ; Smoking ; Papillomaviridae ; Endoscopy ; Digestive system ; Stomach

Sažetak
Helicobacter (H.) pylori is the cause of one of the most common chronic bacterial infections in humans. Risk factors for the development of laryngeal cancer are cigarette smoke, alcohol, and human papillomavirus. Several papers report on H. pylori isolated in tooth plaque, saliva, middle ear and sinuses. Many articles describe the presence of H. pylori in laryngeal cancer cases, however, without nothing the possible source of infection, i.e. stomach or olal cavity. The aim oft his study was to determine which patients and to what extent simultaneously developed H. pylori colonization in the stomach nad the larynx. Prospective examination were performed in 51 patients with laryngeal squamous cell carcinoma. The study group included patients withe laryngeal squamous cell carcinoma histopathologically confirmed by two independent pathologists. The patients underwent fiber esophagogastroduodenoscopy with tumor tissue biopsy. Laryngeal and gastric biopsies were examined by histologic staining technique for histopathologic detection of H. pylori and with DNA analyses using the standardized fluorescent ABI Helicobacter plus-minus PCR assay. Laryngeal carcinoma patients showed positive H. pylori test results simultaneously int he laryngeal and stomach areas, implying H. pylori transmission from the stomach to the laryngeal area. In addition, H. pylori positive test results along with negative H. pylori results in the stomach region were also recorded, suggesting a possible bacteria migration from the oral cavity. In conclusion, H. pylori was found in the area of laryngeal carcinoma, and its migration appeared likely to occur both upwards (from the stomach to the mouth) and downwards (from the oral cavity to the stomach).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA