Naslov
Early menopause contributes to aromatase inhibitor-associated bone loss

Autori
Bojanić, Kristina ; Smolić, Martina ; Ivanac, Gordana ; Štimac, Damir ; Sikora, Miroslav ; Arambašić-Curić, Darija ; Smolić, Robert ; Kuna, Lucija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, ostalo, znanstveni

Skup
The European Congress of Radiology(ECR)

Mjesto i datum
Beč, Austrija, 27.02.2018. - 03.03.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Osteoporosis, Drugs / Reactions, Demineralisation-Bone, Treatment effects, Comparative studies, Oncology, Breast, Bones, Absorptiometry / Bone densitometry

Sažetak
Breast cancer (BC) is the most prevalent cancer in the world with the incidence of 1.67 million in 2012. It is the most common cancer site with 26 % of all cancer sites in females. Treatment of BC is multidisciplinary and includes surgery, radiation, chemotherapy and adjuvant endocrine therapy in cases of hormone receptor (HR)-positive BC.Data from several clinical trials have shown that aromatase inhibitor- associated bone loss (AIBL) at the lumbar spine and hip surpass the gradual bone loss of 1% per year observed in healthy postmenopausal women (7-10). Third-generation AIs (exemestane, letrozole, and anastrozole), as potent inhibitors of estrogen production, have demonstrated superior efficacy and better overall safety in the adjuvant treatment of ER- positive BC, compared with the SERM (11, 12). However, AIs reducing the conversion of steroids to estrogen, consequently lower estrogen levels, increase bone turnover and result in the loss of bone mass. AIBL occurs at a rate of 2-3 fold higher than bone loss in healthy, age-matched postemopausal controls, resulting in significantlly higher incidence of fractures (13).Our results are in accordance with other recent studies and support the fact that during menopause the physiological reduction in ovarian production of estrogen is associated with rapid bone loss in the first 4- 8 years and after menopause residual estrogen levels are important for maintaining bone density (13).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA