Naslov
The role of Lactobacillus reuteri DSM 17938 in nutritional recovery and treatment of constipation in children and adolescents with anorexia nervosa - a randomised, double blind, placebo controlled study

Autori
Žaja, Orjena ; Fiolić, Maja ; Bradovski, Zlata ; Astrom, Mikael

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
J Pediatr Gastroenterol Nutr / Szajewska, Hana - Ženeva, 2018, 1041-1041

Skup
51th Annual meeting of The European Society of Paediatric Gastroenterology, Hepatolology and Nutrition (ESPGHAN)

Mjesto i datum
Ženeva, Švicarska, 09.05.2018. - 12.05.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
anorexia nervosa, Lactobacillus reuteri, constipation, nutritional recovery, children

Sažetak
Objectives and Study: Anorexia nervosa (AN) is a condition of self-induced weight loss that in children and adolescents can result in numerous metabolic complication. Dysmotility is one of the most frequent gastrointestinal disturbance and often difficult to manage. Intestinal microbiota plays an important role in gut motility and thus probiotics are commonly recommended for management of constipation. The data on the probiotic use in patients with AN and constipation are scarce. There is only few studies about the role of the probiotics in patient with AN, and all of them are on the adult population. Since there is no paediatric study, we chose Lactobacillus reuteri DSM 17938 to investigate its role in nutritional recovery and treatment of constipation in children and adolescents with AN. Method: In total, our randomised, double blind, placebo controlled study included 31 female paediatric patients with AN and constipation (according to APA DSM-V and Rome III criteria) reffered to gastroenterologist at the Department of Pediatric Gastroenterology, Hepatology and Nutrition, University Hospital Sestre milosrdnice Zagreb. Patients, randomly assigned into the L. reuteri or Placebo group after being hospitalized, were taking L. reuteri or Placebo for 3 months, along with the conventional nutritional rehabilitation and additional enteral nutrition. They were regularly measured and followed 6 months after initiation of treatment. The primary outcome was relief of constipation (drop-out from Rome III criteria), assessed after 3 months. Secondary outcomes were normalization of body weight (Z-score for BMI less than -1.5, or normalisation of menstrual cycle), normalisation of stool frequency and consistency, weight gain and recovery of malnutrition regarding bone density and vitamin D3 serum levels, 6 months after initiation of treatment. Results: In L.reuteri group 13/15 patients (87%), and 10/16 patients (63%) from Placebo group were relieved of constipation after 3 months. There was no statistically significant difference between the two groups (p-value 0.22). After 6 months, 14/15 patients (93%) in L.reuteri group and 10/16 (63%) in Placebo group achieved normalization of body weight (p-value 0.04). There was a statistically significant difference between the two groups considering the stool frequency (per week) after 6 months (p-value 0.04). Although there was a positive trend considering the bone density recovery and vitamin D3 levels after 6 months, it was no significant which can be explained by the short period of observation. Conclusion: This is the first study with Lactobacillus reuteri DSM 17938 in children and adolescents with AN and constipation. L.reuteri DSM 17938 was more effective than placebo in improving bowel movements and normalization of body weight in children and adolescents with AN. L.reuteri DSM 17983 showed positive trend considering the bone density recovery and vitamin D3 levels after 6 month. On the basis of our results probiotics can potentially serve as simple and safe treatment for constipation in AN

Izvorni jezik
Engleski

Napomena
RAD JE NAGRAĐEN: POSTER OF DISTINCTION'

POVEZANOST RADA