Naslov
Contribution of the HNE-immunohistochemistry to modern pathological concepts of major human diseases

Autori
Žarković, Kamelija ; Jakovčević, Antonia ; Žarković, Neven

Izvornik
Free radical biology & medicine (0891-5849) 111 (2017); 110-126

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
4-Hydroxy-2-nonenal (HNE) ; Lipid peroxidation ; Oxidative stress ; Pathology ; Pathophysiology ; Disease ; Immunohistochemistry ;

Sažetak
Excessive production of reactive oxygen species can induce peroxidation of the polyunsaturated fatty acids thus generating reactive aldehydes like 4-hydroxy-2-nonenal (HNE), denoted as "the second messenger of free radicals". Because HNE has high binding affinity for cysteine, histidine and lysine it forms relatively stable and hardly metabolized protein adducts. By changing structure and function of diverse structural and regulatory proteins, HNE achieves not only cytotoxic, but also regulatory functions in various pathophysiological processes. Numerous animal model studies and clinical trials confirmed HNE as one of the crucial factors in development and progression of many disorders, in particular of cancer, (neuro) degenerative, metabolic and inflammatory diseases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA