Naslov
Enantioselective syntheses of beta-amino alcohols catalyzed by recyclable chiral Fe(III) metal complex

Autori
Tak, Rajkumar ; Kumar, Manish ; Kureshy, Rukhsana I. ; Choudhary, Manoj Kumar ; Khan, Noor-ul H. ; Abdi, Sayed H. R. ; Bajaj, Hari C.

Izvornik
RSC Advances (2046-2069) 6 (2016), 9; 7693-7700

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adrenergic blocking agents ; ring-opening reactions ; schiff-base complexes ; meso-epoxides ; aromatic-amines ; henry reaction ; stereoselective-synthesis ; organic framework ; anilines ; desymmetrization

Sažetak
An efficient asymmetric desymmetrization of meso-epoxides with anilines catalysed by a series of simple and environmentally benign in situ generated Fe(III) complexes based on chiral tridentate ligands L-1-L-7 with achiral and chiral linkers (methylene, piperazine, R/S BINOL and diethyl tartrate) was carried out at rt. The in situ generated iron metal complex based on ligand L(5)a emerged as improved (low catalyst loading) catalyst for asymmetric desymmetrization of meso-epoxides with anilines giving high enantioselectivity (up to 99%) and high yield (95%) of enantiopure beta-amino alcohols in 14 h. While excellent results for ARO of cyclic as well as aliphatic epoxides with anilines was achieved with in situ generated complex from the ligand L(4)h and Fe(III) chloride, the catalyst was recoverable and recyclable (five times) with retention of its performance

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti

POVEZANOST RADA