Pregled bibliografske jedinice broj: 940
Slow autoxidation of LDL spares alpha-tocopherol
Slow autoxidation of LDL spares alpha-tocopherol // Abstracts of the XIth International Symposium on Atherosclerosis ; u: Atherosclerosis 134 (1997)(1/2) ; 3.P.65 / Schaefer, E.J. ; Seidel, D. ; Shepard, J. (ur.).
Amsterdam: Elsevier, 1997. str. 212-212 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 940 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Slow autoxidation of LDL spares alpha-tocopherol
(Slow autoxidation of LDL spares alpha-tocopher)
Autori
Herak, Janko Nikola ; Stojanović, Nataša ; Krilov, Dubravka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstracts of the XIth International Symposium on Atherosclerosis ; u: Atherosclerosis 134 (1997)(1/2) ; 3.P.65
/ Schaefer, E.J. ; Seidel, D. ; Shepard, J. - Amsterdam : Elsevier, 1997, 212-212
Skup
XIth International Symposium on Atherosclerosis
Mjesto i datum
Pariz, Francuska, 05.10.1997. - 09.10.1997
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
LDL oxidation; lipoproteins; tocopherol
Sažetak
Slow oxidation of LDL is characterized by tocopherol-mediated peroxidation (TMP). Here we show that in very slow TMP alpha-tocopherol is not used to a detectable level. Buffered LDL (with presence of EDTA) undergoes slow autoxidation at physiological temperature. In a closed system, after a lag period of about one day, oxygen is consumed and peroxides formed. The process is followed by reduction of the peroxides and simultaneous appearance of free radicals that are trapped predominantly on the apoproteins. In the above process no change of alpha-tocopherol level has been detected. Under our experimental conditions oxidation is probaly initiated by very few (chelated) transition-metal ions in only few LDL particles. In the initial phase (lag phase) tocopherol is protected or the tocopheroxyl radical regenerated by ubiquinol-10 and/or some other lipid-soluble antioxidant, in a way that is not well understood. In the propagation phase tocopherol reversibly flips between the oxidized and reduced forms, serves as a chain-transfer reagent and keeps the oxidation process active. After dissolved oxygen is consumed , tocopherol participates in the samne manner in the formation of the lipid-centered free radicals. The L. radicals react with the protein moiety (radical fixation to protein) and terminats the process.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Napomena
Doi: 10.1016/S0021-9150(97)89094-6
