Naslov
Neonatal alloimmune thrombocytopenia caused by anti-HLA-A24 alloantibodies

Autori
Starcevic, M ; Tomicic, M ; Malenica, M ; Zah- Matakovic, V

Izvornik
Acta Paediatrica (0803-5253) 99 (2010), 4; 630-632

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
neonatal alloimune thrombocytopenia

Sažetak
Neonatal alloimmune thrombocytopenia (NAIT) occurs as a result of maternal alloimmunization against paternally inherited antigens on foetal platelets. Platelets express platelet specific antigens (HPA) along with human leucocyte antigens (HLA) class I. Although anti-HLA class I antibodies are often detectable in pregnant women, their role in NAIT is considered controversial. We report a case of NAIT where the most sensitive serological analysis and molecular methods could not detect platelet specific antibodies. Only HLA incompatibility and presence of anti-HLA-A24 antibodies in both the mother's and the newborn's serum were proven. CONCLUSION: This case supports the idea that some anti-HLA class I antibodies could cause NAIT.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA