Naslov
Neutrophil/lymphocyte ratio as a predictive value for treatment outcome after neoadjuvant therapy in locally advanced breast cancer patients

Autori
Raguž, Jelena ; Vuković, Petra ; Marinčić, Iva ; Vincelj, Nikolina ; Bilić Knežević, Sara ; Badžek, Iva ; Šeparović, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Libri oncologici / Vrdoljak, Danko Velimir ; Vrbanec, Damir ; Tečić Vuger, Ana - Zagreb : Klinički bolnički centar Sestre milosrdnice, 2017, 71-71

Skup
1st Regional Congress of Medical Oncology and 1st Regional Congress of Oncology Pharmacy

Mjesto i datum
Dubrovnik, Hrvatska, 04.05.2017. - 07.05.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
breast cancer, neoadjuvant therapy, inflammation, neutrophil/lymphocyte ratio

Sažetak
Inflammation has an important role in cancer progression, as neutrophils and lymphocytes are thought to be signifi cant in tumour immunology and infl ammation. Neutrophil/lymphocyte ratio (NLR)is used as a marker of subclinical inflammation. In several malignancies prognostic value of NLR was demonstrated, indicating that elevated NLR determines worse prognosis of the patients. The aim of this study was to determine the relationship between pretreatment NLR values and pathologic complete response after neoadjuvant therapy in locally advanced breast cancer patients. Retrospectively we identifi ed 117 patients with breast carcinoma (BC) treated with neoadjuvant chemotherapy (NCT) at University Hospital for tumors in Zagreb. 79 patients fi nished NCT and underwent surgery so theirs data were further analyzed. Pathological complete response (pCR) was defi ned by absence of invasive cancer in resected breast and axillary tissue. Value of NLR was measured at the start of neoadjuvant treatment by dividing the number of neutrophils by the number of lymphocytes. Median age was 55 years. Pathological complete response (pCR) was achieved in 24% BC patients treated with NCT (47% luminal B, 53% hormone receptor negative BC). NLR ranged from 0.94 to 5.22. The median NLR values were similar in both pCR and non-pCR arm (2.3 vs. 2.38). Pathological complete response (pCR)was achieved in 31% patients with low NLR (<2.0) and in 19% of patients with higher NLR (>2.0). There were also no signifi cant diff erences regarding BC subtypes. There was no relationship between the pCR and pretreatment NLR values.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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