Naslov
Elimination of tramadol and methadone in model ozonation experiments: removal kinetics and identification of transformation products

Autori
Kostanjevečki, Petra ; Ćurko, Josip ; Matošić, Marin ; Ahel, Marijan ; Terzić, Senka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
SETAC Europe 28th Annual Meeting Abstract Book / - : Society of Environmental Toxicology and Chemistry (SETAC), 2018, 205-205

Skup
SETAC Europe 28th Annual Meeting

Mjesto i datum
Rim, Italija, 13.05.2018. - 17.05.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
ozonation ; tramadol ; methadone ; transformation products

Sažetak
Since the conventional wastewater treatment has proven to be ineffective for a number of pharmaceutical compounds, there is a high concern about their ever-increasing release into the aquatic environment. To mitigate this problem, advanced wastewater treatment technologies, such as advanced oxidation and membrane filtration, are often necessary to reduce the emissions to acceptable levels and/or to minimize the possible overall ecotoxicity of the effluents. Therefore, the aim of this work was to examine the removal of two opioid analgesics, tramadol and methadone, using ozonation. The experiments were performed in three different matrices, including pure water, phosphate buffer and secondary effluent from the Central wastewater treatment plant of the city of Zagreb. The removal rate of opioid analgesics was systematically studied as a function of ozone concentration, pH and matrix used to dissolve target compounds. The determination of the remaining concentration of selected compounds as well as identification of transformation products formed during the experiment were performed by ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. The experiment showed that ozonation at an ozone dosage of 0.05 - 0.5 mg/L completely removed both opioid compounds in less than 5 min in pure water and phosphate buffer solution, providing that pH of the ozonation medium was higher than 7. The elimination of opioids was significantly slowed down at acidic conditions, which indicated the importance of the amino group deprotonation for an efficient reaction with ozone. Elimination of selected compounds in secondary effluent was much slower than in organic-free water matrices, reaching 91.1% and 99.1% in the time period of 10 minutes for tramadol and methadone, respectively. Reason for the lower elimination percentage is ozone depletion by reaction with other organic compounds present in the secondary effluent. The removal of parent compounds was associated with formation of two main transformation products characterized by m/z values of 250 and 280 for tramadol and 278 and 294 for methadone. The most abundant transformation products of tramadol and methadone were tentatively identified as tramadol N-oxide and EDDP, respectively.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Kemijsko inženjerstvo, Interdisciplinarne tehničke znanosti

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