Naslov
Association of Chronotype and Daytime Sleepiness with Myocardial Infarction.

Autori
Škrlec, Ivana ; Milić, Jakov ; Heffer, Marija ; Steiner, Robert ; Peterlin, Borut ; Wagner, Jasenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9th ISABS Conference on Forensic and Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine / - , 2015

ISBN
978-953-57695-1-4

Skup
9th ISABS Conference on Forensic and Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine

Mjesto i datum
Bol, Hrvatska, 22.06.2015. - 26.06.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cardiovascular diseases ; chronotype ; circadian rhythm ; myocardial infarction ; sleepiness

Sažetak
Human physiological activities and diseases are under the control of circadian rhythm. The circadian rhythm is regulated by the suprachiasmatic nucleus (SCN) and multiple circadian clock genes. Sleep disorders are associated with vascular outcomes such as myocardial infarction (MI). Circadian rhythm is under the influence of lifestyle that can lead to MI. We conducted a cohort study of 200 patients who were hospitalized because MI and 200 healthy controls. Systematic information on the past and current medical history, plus the demographic variables was collected from each participant. Chronotype was assessed with the Morningness- Eveningness Questionnaire (MEQ) and daytime sleepiness with the Epworth Sleepiness Scale (ESS). Mean age of the study population was 64.1±12.8 years and 54.5% were males. No significant difference was found in MEQ scores among male patients versus male controls (59.3±6.4 vs. 58.3±7.6, p=0.909) and no significant difference in ESS score among two female groups (5.8±3.4 vs. 5.8±3.9, p=0.102). MEQ is associated with age in male patients (p=0.00026), but not in male controls and females. A significant association was found between ESS and dyslipidemia in patients (p=0.005) but not in the controls (p=0.228). ESS was associated with family anamneses of cardiovascular diseases in patients but not in the controls (p=0.008 vs. p=0.58). MEQ was associated with non-smoking in controls (p=0.0018). Risk factors for cardiovascular diseases, such as age, dyslipidemia, smoking, are associated with MEQ or ESS. There have been no studies to our knowledge looking specifically for differences in circadian rhythm among the MI patients and healthy controls.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

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