Naslov
Sensitivity of mumps virus to the action of IFN-α subtypes

Autori
Markušić, Maja ; Šantak, Maja ; Košutić-Gulija, Tanja ; Jergović, Mladen ; Jug, Renata ; Forčić, Dubravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Croatian Immunological Society 2014 Annual Meeting, Book of Abstracts / - , 2014, 69-69

Skup
Croatian Immunological Society 2014 Annual Meeting

Mjesto i datum
Krk, Hrvatska, 17.10.2014. - 18.10.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
mumps virus ; IFN-α subtypes ; antiviral response

Sažetak
Human type I interferons (IFNs), predominantly IFN-α and IFN-β, are known to play an important role in early host antiviral response. The IFN- α family consists of even 12 subtypes which despite their high structural homology and signaling through the same receptor have different antiviral, antiproliferative and immunomodulatory activities. Differences in the production of IFN-α subtypes therefore determine the quality of an antiviral response. The aim of this study was to examine the pattern of IFN-α subtypes induced in mumps virus (MuV) infection and then to assess the sensitivity of MuV to the action of IFN-α subtypes. Our results show that all IFN-α subtypes are expressed in response to MuV infection and that pattern of their expression is similar regardless of the virus strain used. Our data demonstrate that all tested IFN-α subtypes can suppress MuV replication, however the intensity and pattern of their action are dependent on a virus strain.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA