Naslov
Unusual features of metastatic atypical carcinoid of the larynx

Autori
Alujević, A. ; Jurić, G. ; Šeparovi, ć Robert ; Krušlin Božo

Izvornik
European archives of oto-rhino-laryngology (0937-4477) 255 (1998), 6; 318-321

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Larynx ; neuroendocrine carcinoma ; carcinoid tumor ; paraganglioma ; metastasis

Sažetak
This report describes a case of atypical carcinoid of the larynx with metastatic tumor to cervical lymph nodes showing features similar to paraganglioma. Immunohistochemically, both the primary and metastatic tumor were positive for epithelial membrane antigen, cytokeratin, neuron- specific enolase, chromogranin, synaptophysin, calcitonin and carcinoembryonic antigen. The sustentacular cells in pseudo-cell ball (“Zellballen”) formations were shown by a positive S-100 marker. Electron microscopic analysis revealed numerous neuroendocrine granules measuring 150–250 nm in diameter. Clinical features, histological appearance, histochemical, immunohistochemical and ultrastructural findings, as well as differential diagnosis are discussed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA