Naslov
The first report on ochratoxin A concentration in the kidneys of the European brown bear (Ursus arctos L.)

Autori
Rašić, Dubravka ; Lazarus, Maja ; Huber, Đuro ; Reljić, Slaven ; Peraica, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of 10th Congress of Toxicology in Developing Countries (CTDC10) and 12th Congress of the Serbian Society of Toxicology (12th STC) / Matović, Vesna - Beograd : Serbian Society of Toxicology, 2018, 148-149

ISBN
978-86-917867-1-7

Skup
10th Congress of Toxicology in Developing Countries (CTDC 10) ; 12th Serbian Congress of Toxicology

Mjesto i datum
Beograd, Srbija, 18.04.2018. - 21.04.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
brown bear, HPLC, kidneys, maize, ochratoxin A

Sažetak
Ochratoxin A (OTA) is a nephrotoxic and carcinogen mycotoxin that contaminates different food commodities. Its toxicokinetics and accumulation in plasma, kidneys and liver are species-specific. The European brown bear (Ursus arctos L.) is the largest terrestrial mammal in Croatia and most its diet consists of plant food. Maize from supplemental feeding sites makes up an important part of the bears’ diet, especially in periods and years of low natural food resources. This supplemental maize is often of poor quality to begin with and is further adulterated by weather conditions, which enhance the production of OTA. We hypothesized that the OTA level in kidneys would reflect the intake of OTA-contaminated maize. A total of 56 kidney samples were collected (19 samples in 2013 and 37 samples in 2015) from bears hunted according to the Brown Bear Management Plan in Croatia. After liquid- liquid extraction, OTA concentration was measured using HPLC with a florescent detector. Regression analysis revealed that OTA concentration was significantly lower (13.82 ± 12.55 ng g-1 tissue ; median 12.25) in samples collected during 2013 than in samples collected during 2015 (142.30 ± 237.53 ng g-1 tissue, median 53.31), while controlling for age, sex and season of collection (b=0.60, p<0.001, R2=0.46). These results are the first report on OTA concentrations in the kidney of the European brown bear. OTA in bear kidneys depends on the specific diet habits, bears’ microlocation, quality of supplemental food and the conditions of food storage.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Veterinarska medicina

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