Pregled bibliografske jedinice broj: 930509
New insights into HEATR1 functions
New insights into HEATR1 functions // Cell cycle, 17 (2018), 2; 143-144 doi:10.1080/15384101.2017.1411325 (recenziran, članak, znanstveni)
CROSBI ID: 930509 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
New insights into HEATR1 functions
Autori
Bursać, Slađana ; Jurada, Deana ; Volarević, Siniša
Izvornik
Cell cycle (1538-4101) 17
(2018), 2;
143-144
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
HEATR1 ; ribosome biogenesis ; p53
Sažetak
Human HEAT repeat containing 1 protein (HEATR1) is the structural and functional homolog of yeast U3 small nucleolar RNA-associated protein 10 (UTP 10). Human HEATR1 is a nucleolar protein that plays a prominent positive role in regulation of rRNA synthesis. Depletion of HEATR1 cause disruption of nucleolar structure and activate the ribosomal biogenesis stress pathway – RPL5 / RPL11 dependent stabilization and activation of the tumor suppressor protein p53.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Napomena
News and Views to: Turi Z et. al. Perturbation of
RNA Polymerase I transcription machinery by
ablation of HEATR1 triggers the RPL5/RPL11- MDM2-
p53 ribosome biogenesis stress checkpoint pathway
in human cells. Cell Cycle 2017
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
