Naslov
Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis

Autori
Lindström, Mikael S ; Jurada, Deana ; Bursac, Sladana ; Orsolic, Ines ; Bartek, Jiri ; Volarevic, Sinisa

Izvornik
Oncogene (0950-9232) 37 (2018), 18; 2351-2366

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
nucleolus, nucleolar chromatin, rDNA damage and repair, genome instability, cancer

Sažetak
The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that are responsible for protein synthesis. A wealth of research over the past 20 years has clearly indicated that both quantitative and qualitative alterations in ribosome biogenesis can drive the malignant phenotype via the dysregulation of protein synthesis. However, numerous recent proteomic, genomic and functional studies have implicated the nucleolus in the regulation of processes that are unrelated to ribosome biogenesis, including the DNA damage response, the maintenance of genome stability and its spatial organization, epigenetic regulation, cell-cycle control, stress responses, senescence, global gene expression as well as assembly or maturation of various ribonucleoprotein particles. In this review, the focus will be on features of rDNA genes which make them highly vulnerable to DNA damage and intra- and interchromosomal recombination as well as built-in mechanisms that prevent and repair rDNA damage, and how dysregulation of this interplay affects genome- wide DNA stability, gene expression and the balance between euchromatin and heterochromatin. We will also present the most recent insights into how malfunction of these cellular processes may be a central driving force of human malignancies, and propose a promising new therapeutic approach for the treatment of cancer.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA