Naslov
RNA adenylation during oocyte-to-embryo transition in mice

Autori
Loubalová, Zuzana ; Urbanová, Jana ; Malík, Radek ; Chalupníková, Katerina ; Ryan, Claire ; Ganesh, Sravya ; Franke, Vedran ; Karlic, Rosa ; Vlahovicek, Kristian ; Svoboda, Petr

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
RNA 2017, The 22nd Annual Meeting of the RNA Society, PROGRAM & ABSTRACTS / Barta, Andrea ; Green, Rachel ; Lima, Christopher ; Micura, Ron ; Svoboda, Petr ; Tomari, Yukihide - Prag, 2017, 271-271

Skup
RNA 2017, The 22nd Annual Meeting of the RNA Society

Mjesto i datum
Prag, Češka Republika, 30.05.2017. - 03.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
development ; embryo ; RNA adenylation ; mRNA processing

Sažetak
All animal embryos undergo a transition during which development is handed from maternal to the zygotic control. In mouse, the oocyte-to-embryo transition is a highly coordinated process largely relying on post-transciptional mechanisms because of transcriptional quiescence between the fully-grown oocyte stage and the activation of gene expression in a cleaving zygote. This makes mechanisms of post-transcriptional control of gene expression primary candidates for essential control elements of the maternal to zygotic transition. One of such mechanisms is covalent modification of RNA 3‘ termini by a family of RNA-specific ribonucletidyl transferases, which add A or U ribonucleotides at the 3´ terminus. Covalent modifications at 3‘ termini plays a role in processing of eukaryotic messenger RNA precursors, control of translation, and RNA quality control. Here, we report our analysis of RNA adenylation during oocyte-to-embryo transition in mice where the maternal transcriptome undergoes distinct waves of RNA adenylation and deadenylation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA