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Pregled bibliografske jedinice broj: 929386

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlić, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro et al.
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations // Journal of hepatology, 68 (2018), 5; 959-969 doi:10.1016/j.jhep.2018.01.009 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 929386 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

Autori
Wardell, Christopher P. ; Fujita, Masashi ; Yamada, Toru ; Simbolo, Michele ; Fassan, Matteo ; Karlić, Rosa ; Polak, Paz ; Kim, Jaegil ; Hatanaka, Yutaka ; Maejima, Kazuhiro ; Lawlor, Rita T. ; Nakanishi, Yoshitsugu ; Mitsuhashi, Tomoko ; Fujimoto, Akihiro ; Furuta, Mayuko ; Ruzzenente, Andrea ; Conci, Simone ; Oosawa, Ayako ; Sasaki-Oku, Aya ; Nakano, Kaoru ; Tanaka, Hiroko ; Yamamoto, Yujiro ; Michiaki, Kubo ; Kawakami, Yoshiiku ; Aikata, Hiroshi ; Ueno, Masaki ; Hayami, Shinya ; Gotoh, Kunihito ; Ariizumi, Shun-ichi ; Yamamoto, Masakazu ; Yamaue, Hiroki ; Chayama, Kazuaki ; Miyano, Satoru ; Getz, Gad ; Scarpa, Aldo ; Hirano, Satoshi ; Nakamura, Toru ; Nakagawa, Hidewaki

Izvornik
Journal of hepatology (0168-8278) 68 (2018), 5; 959-969

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Biliary tract cancer ; Cell origin ; Cholangiocarcinoma ; Driver gene ; Genome sequencing ; Predisposing mutation

Sažetak
We here analyzed genomic features of 412 BTC samples from Japanese and Italian populations. A total of 32 significantly and commonly mutated genes were identified, some of which negatively affected patient prognosis, including a novel deletion of MUC17 at 7q22.1. Cell-of-origin predictions using WGS and epigenetic features suggest hepatocyte-origin of hepatitis-related ICCs. Deleterious germline mutations of cancer-predisposing genes were detected in 11% of patients with BTC. BTCs have distinct genetic features including somatic events and germline predisposition.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Projekti:
KK.01.1.1.01.0009 - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima (EK )
KK.01.1.1.01.0010
HRZZ-IP-2014-09-6400 - Istraživanje razvoja, diferencijacije i evolucije životinja kroz genomiku bazalnih metazoa (BAMGEN) (Vlahoviček, Kristian, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Rosa Karlić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Wardell, Christopher P.; Fujita, Masashi; Yamada, Toru; Simbolo, Michele; Fassan, Matteo; Karlić, Rosa; Polak, Paz; Kim, Jaegil; Hatanaka, Yutaka; Maejima, Kazuhiro et al.
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations // Journal of hepatology, 68 (2018), 5; 959-969 doi:10.1016/j.jhep.2018.01.009 (međunarodna recenzija, članak, znanstveni)
Wardell, C., Fujita, M., Yamada, T., Simbolo, M., Fassan, M., Karlić, R., Polak, P., Kim, J., Hatanaka, Y. & Maejima, K. (2018) Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations. Journal of hepatology, 68 (5), 959-969 doi:10.1016/j.jhep.2018.01.009.
@article{article, author = {Wardell, Christopher P. and Fujita, Masashi and Yamada, Toru and Simbolo, Michele and Fassan, Matteo and Karli\'{c}, Rosa and Polak, Paz and Kim, Jaegil and Hatanaka, Yutaka and Maejima, Kazuhiro and Lawlor, Rita T. and Nakanishi, Yoshitsugu and Mitsuhashi, Tomoko and Fujimoto, Akihiro and Furuta, Mayuko and Ruzzenente, Andrea and Conci, Simone and Oosawa, Ayako and Sasaki-Oku, Aya and Nakano, Kaoru and Tanaka, Hiroko and Yamamoto, Yujiro and Michiaki, Kubo and Kawakami, Yoshiiku and Aikata, Hiroshi and Ueno, Masaki and Hayami, Shinya and Gotoh, Kunihito and Ariizumi, Shun-ichi and Yamamoto, Masakazu and Yamaue, Hiroki and Chayama, Kazuaki and Miyano, Satoru and Getz, Gad and Scarpa, Aldo and Hirano, Satoshi and Nakamura, Toru and Nakagawa, Hidewaki}, year = {2018}, pages = {959-969}, DOI = {10.1016/j.jhep.2018.01.009}, keywords = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, journal = {Journal of hepatology}, doi = {10.1016/j.jhep.2018.01.009}, volume = {68}, number = {5}, issn = {0168-8278}, title = {Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations}, keyword = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation} }
@article{article, author = {Wardell, Christopher P. and Fujita, Masashi and Yamada, Toru and Simbolo, Michele and Fassan, Matteo and Karli\'{c}, Rosa and Polak, Paz and Kim, Jaegil and Hatanaka, Yutaka and Maejima, Kazuhiro and Lawlor, Rita T. and Nakanishi, Yoshitsugu and Mitsuhashi, Tomoko and Fujimoto, Akihiro and Furuta, Mayuko and Ruzzenente, Andrea and Conci, Simone and Oosawa, Ayako and Sasaki-Oku, Aya and Nakano, Kaoru and Tanaka, Hiroko and Yamamoto, Yujiro and Michiaki, Kubo and Kawakami, Yoshiiku and Aikata, Hiroshi and Ueno, Masaki and Hayami, Shinya and Gotoh, Kunihito and Ariizumi, Shun-ichi and Yamamoto, Masakazu and Yamaue, Hiroki and Chayama, Kazuaki and Miyano, Satoru and Getz, Gad and Scarpa, Aldo and Hirano, Satoshi and Nakamura, Toru and Nakagawa, Hidewaki}, year = {2018}, pages = {959-969}, DOI = {10.1016/j.jhep.2018.01.009}, keywords = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation}, journal = {Journal of hepatology}, doi = {10.1016/j.jhep.2018.01.009}, volume = {68}, number = {5}, issn = {0168-8278}, title = {Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations}, keyword = {Biliary tract cancer, Cell origin, Cholangiocarcinoma, Driver gene, Genome sequencing, Predisposing mutation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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