Naslov
IgG avidity: an important serologic marker for the diagnosis of tick-borne encephalitis virus infection

Autori
Vilibić-Čavlek, Tatjana ; Barbić, Ljubo ; Stevanović, Vladimir ; Petrović, Goranka ; Mlinarić-Galinović, Gordana

Izvornik
Polish Journal of Microbiology (1733-1331) 65 (2016), 1; 119-121

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tick-borne encephalitis virus ; IgG avidity

Sažetak
A total of 52 serum samples from patients with symptoms suggestive of tick-borne encephalitis virus (TBEV) infection and positive IgM and/or IgG antibodies were tested for IgG avidity. Acute/recent TBEV infection was confirmed by low/borderline avidity index (AI) in 94.8% IgM positive/IgG positive samples, while in 5.2% high AI was found indicating persisting IgM antibodies. Majority of IgM negative/IgG positive samples (78.6%) showed high AI consistent with past TBEV infection. However, in 21.3% patients without measurable IgM antibodies current/recent infection was confirmed by AI. IgG avidity represents an additional serologic marker that improves diagnosis of TBEV, especially in cases of atypical antibody response.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Veterinarska medicina

POVEZANOST RADA