Naslov
Prevalence of lymphocytic choriomeningitis antibodies in persons with rodent exposure

Autori
Oreški, Tena ; Korva, Miša ; Vilibić-Čavlek, Tatjana ; Stevanović, Vladimir ; Jeličić, Pavle ; Miklaušić, Božana ; Barbić, Ljubo ; Tabain, Irena ; Avšič-Županc, Tatjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Book of Abstracts.7th International Congress "Veterinary Science and Profession". / - Zagreb : Veterinarski fakultet Sveučilišta u Zagrebu, 2017, 54-54

Skup
7th International Congress "Veterinary Science and Profession"

Mjesto i datum
Zagreb, Hrvatska, 05.10.2017. - 07.10.2017

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Lymphocytic choriomeningitis virus ; Seroprevalence

Sažetak
Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen associated with aseptic meningitis, fatal infections in immunocompromised persons and congenital infections. The natural rodent host and principal reservoir for LCMV is the house mouse (Mus musculus). Humans become infected by inhaling infectious aerosols or by ingesting contaminated food. The incidence of clinically significant LCMV infection in humans is unknown. Seroepidemiological studies in the general population revealed the seroprevalence of 5-10%. During a one-year period (June 2016- May 2017), a total of 94 serum samples collected from persons exposed to rodents were tested for the presence of LCMV IgG antibodies using indirect immunofluorescence assay (IFA). All participants were asymptomatic and did not report recent febrile disease. In the tested group, there were 88 (93.6%) males and 6 (6.4%) females aged 25- 71 years from continental Croatian counties. In addition to contact with rodents through occupational exposure (forestry workers, hunters, agriculture workers), rodent infestations around house/resting house and cleaning rodent-infested areas, the majority of participants reported some other potential risk factors, such as frequent visits to forest areas and food storage in basements. LCMV IgG antibodies were detected in 9 (9.5%) tested persons at low titers (16 and 32, respectively). The seropositive persons were from northwestern (Zagreb area) and eastern (Slavonski Brod area) regions. Our results indicate that LCMV is present in Croatia. Further studies on a larger sample of exposed persons, as well as the general population, are needed to determine the prevalence of this neglected zoonosis.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Veterinarska medicina

POVEZANOST RADA