Naslov
Optimization of the process conditions for the extraction of rutin from Ruta graveolens L. by choline chloride based deep eutectic solvents

Autori
Molnar, Maja ; Jakovljević, Martina ; Jokić, Stela

Izvornik
Solvent Extraction Research and Development, Japan (1341-7215) 25 (2018), 2; 109-116

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
deep eutectic solvents ; extraction ; rutin ; optimization

Sažetak
Extraction of rutin from Ruta graveolens L. leaves was performed in choline chloride based deep eutectic solvents (DESs). Firstly, rutin extraction was performed in five different DESs ; pure DESs and with different amounts of water added (25% and 50% v/v), for different times (1h, 3h and 6h) in order to find the best DES for further optimization. Choline chloride plus citric acid (1:1) was shown to be best DES and optimization of rutin extraction was performed using response surface methodology (RSM) based on the selected solvent and applying different extraction parameters: extraction time, temperature and water content. The rutin content was determined by HPLC and varied from 0.55 g/100 g of plant to 1.81 g/100 g of plant depending on the applied conditions. The best conditions for rutin extraction were found to be: a temperature of 70°C, an extraction time of 52 min and a water content of 27% for the extraction of 1.88g /100 g plant.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija

POVEZANOST RADA