Naslov
Experimental and Theoretical Study of Selectivity in Mechanochemical Cocrystallization of Nicotinamide with Anthranilic and Salicylic Acid

Autori
Lukin, Stipe ; Lončarić, Ivor ; Tireli, Martina ; Stolar, Tomislav ; Blanco, Maria V. ; Lazić, Predrag ; Užarević, Krunoslav ; Halasz, Ivan.

Izvornik
Crystal growth & design (1528-7483) 18 (2018), 3; 1539-1547

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mechanochemical selectivity ; mechanochemical cocrystallization ; nicotinamide ; anthranilic acid ; salicylic acid ; in situ Raman monitoring ; in situ PXRD ; tandem in situ monitoring

Sažetak
Selectivity in mechanochemical cocrystal formation between nicotinamide and anthranilic acid or salicylic acid was studied using tandem in situ reaction monitoring by powder X-ray diffraction (PXRD) and Raman spectroscopy. Selectivity was probed by offering a competing cocrystal coformer to a previously prepared cocrystal or under competitive reaction conditions where all cocrystal coformers, in different stoichiometric ratios, were introduced together in the starting reaction mixture. Reaction paths were dependent on the starting mixture composition, and we find that the formation of intermediates and the final product can be predicted from solid-state ab initio calculations of relative energies of possible reaction mixtures. In some cases, quantitative assessment revealed different reaction profiles derived from PXRD and Raman monitoring, directly indicating, for the first time, different mechanochemical reactivity on the molecular and the bulk crystalline level of the reaction mixture.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA