Naslov
Evaluation of a flow-photochemistry platform for the synthesis of functionalized benzobicyclo[3.2.1]-skeleton

Autori
Ratković, Ana ; Kelava, Vanja ; Marinić, Željko ; Škorić, Irena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Central European Conference on Photochemistry (CECP 2018) : Book of Abstracts / - Bad Hofgastein, 2018, 62-62

Skup
Central European Conference on Photochemistry (CECP 2018)

Mjesto i datum
Bad Hofgastein, Austrija, 04.02.2018. - 08.02.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Benzobicyclo[3.2.1]octadienes ; Continuos flow system ; Flow-photochemistry ; Intramolecular photocycloaddition ; Physico-chemical and ADME properties

Sažetak
Bicyclo[3.2.l]-skeleton is a common subunit in many natural products such as diterpenes and sesquiterpenes [1a]. Compounds that have this core as a base have been tested and are proved as potent inhibitors of dopamine and serotonin transporters and also play crucial role in treatment of CNS and Alzheimer’s disorders [1b, c]. On the other hand, photochemical synthesis gave a pathway to a whole library of polycyclic compounds that include a vast number of structures with the benzobicyclo[3.2.1]octadiene moiety [2]. To apply an even more powerful tool for this targeted functionalized substrate, continuous flow photochemical system was used for the first time [3] enabling us to scale-up the intramolecular cycloaddition reaction without scaling-up the equipment. For all of the obtained novel potentially bioactive derivatives preliminary physico-chemical properties were also analyzed

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA