Naslov
Stable gastric pentadecapeptide BPC 157 and insulin induced gastric lesions in rats.

Autori
Ilić, S ; Mester, M ; Filipović, M ; Sever, M ; Klicek, R ; Barisic, I ; Zoričić, Z ; Bilić, V ; Berkopić, L ; Brcic, L ; Brcic, I ; Kolenc, D ; Seiwerth, S ; Sikiric P

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Book of abstracts 13th International conference on gastrointestinal research and 13th internacional conference on ulcer research, Split, Croatia / Sikirić, Predrag - Krakov : Polish Physiological Society, Journal of Physiology and Pharmakology, 2009, 40-40

Skup
13th International conference on gastrointestinal research and 13th internacional conference on ulcer research

Mjesto i datum
Split, Hrvatska, 10.09.2009. - 16.09.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
stable gastric pentadecapeptid BPC 157 ; insulin induced gastric lesions
(stable gastric pentadecapeptid BPC 157 ; insulin induced gastric lesion)

Sažetak
The stable gastric pentadecapeptid BPC 157 (GEPPGKPADDAGLV, M.W. 1419) is a small anti- ulcer peptide efficient in inflammatory bowed disease trials (PL 14736) and various wound tretment, no toxiicity reported. Interestingly, it may have therapeutic effect on acute panckeatitis and act protzectively on endothelium, affects many central disturbances and the NO -system. act as free radical scavenger and exibitneuroprotective properties. So far, BPC 157 effect on insulin administration was not investigated. Material and Methods: Wistar Albino rats werw injected with various insulin preparations (Mixtard, Insaultard, Actrapid, Humulin, insulin (human), Novo Nordisk given intraperitonealy (250 UI/kg). Medication given intraperitoneally at 10 min before insulin administration included saline 5.0 ml/kg (control) or pentadecapeptice BPC 157 (10.micogram, 10.0 nanogram). At the time when the control rats exibited prominent insulin convulsion (i.e., after insulin application at 3h (Mixtard) or after 7h (Insultard, Actrapid, Humulin)., all rats werw sacrificed, and the stomach lesions (sum of largest) lesion diameter (mm) and blood glucose level (mmol/L) were estomated. Results: All of the rats thar recived insulin exibited post-insulin convulsions (starting at 90 min without lesions, and hemorrhagic lesion, otherwise very prominent, werw lacking. Serum glucose level regularly remained within normal range. Also, the post-insulin convulsion werw completely eliminated or markedly attenuated. Conclusion: We showed a so far not recognized ability of BPC 157 ti couteract severe tocix effect of insulin over-dose application.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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