Naslov
Physiological role(s) of IL-15 and IL-18 at the maternal-fetal (M-F) interface. Session: Cytokine regulation in pregnancy

Autori
Rukavina, Daniel ; Bogović, Tatjana ; Sotošek, Vlatka ; Laškarin, Gordana ; Štrbo, Nataša ; Juretić, Koraljka ; Ćupurdija, Kristijan ; Tsuji, Yoshiyuki ; Kojama, Koji

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 8th Congress of the Alps Adria Society for Immunology of Reproduction ; u: American Journal of Reproductive Immunology 48 (2002) (3) ; Invited Lectures 134-144 ; I16 / - , 2002, 139-140

Skup
Congress of the Alps Adria Society for Immunology of Reproduction (8 ; 2002)

Mjesto i datum
Weimar, Njemačka, 07.09.2002. - 10.09.2002

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
decidua; IL-15; IL-18

Sažetak
It is almost dogma that IL-2 is not expressed at the M-F interface during normal pregnancy. However, recent results by ours and others clearly showed that IL-15 -Th1 type cytokine which shares many similarities with IL-2 is expressed at the interface. IL-15 can affect cytolytic activity of maternal decidual lymphocytes which heavily infiltrate maternal decidua during the first trimester pregnancy. These cells are in a direct contact with trophoblastic cells. IL-18 is a recently discovered Th1 type cytokine with many interesting functions. The aim is to examine IL-18 distribution at the interface and its potential in upregulating peripheral blood (PB) and decidual lymphocytes (DL) cytotoxicity. Th1 activated lymphocytes are LAK cells and they can kill by both Perforin and Fas pathways in non MHC restricted manner. PBL and DL were obtained from elective pregnancy termination of pregnancy. IL-18 and IL-18R expression was detected by flow cytometry and immunohistology and cytolytic potential by cytotoxicity against K-562 (NK sensitive) and P815 (NK resistant) cell lines. IL-18 positive cells were found in the suspension of Decidual adherent cells and IL-18 R expressions at the trophoblastic cells of villi. Both IL-15 and IL-18 are increasing cytolytic potential of PBL and DL against NK sensitive cell line. Decidual lymphocytes are activated cells with the potential of killing NK resistant but LAK sensitive lines and this is mediated by both perforin and Fas pathways. Physiological and pathophysiological role(s) of cytolytic pathways and Th1 cytokines (IL-15 and IL-18) at the interface will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Germany Conference venue: 'Neue Weimarhalle'.

POVEZANOST RADA