Naslov
Regulatory circuits of inflammatory cytokines at interface

Autori
Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book / Kurpisz Maciej - Poznań, 2000

Skup
The 3rd Congress of ESRADI

Mjesto i datum
Poznań, Poljska, 19.11.2000. - 21.11.2000

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
TH1; TH2; Cytokines; IL-2; IL-15; CTL; dNK cells; Perforin; IL-18

Sažetak
The current dogma in reproductive immunology is that in pregnancy potentially harmful TH1 (cell-mediated) responses are suppressed whereas TH2 (antibody-mediated) responses are normal. However, there are data showing that this is an over-simplification and that while adaptive immune responses are suppressed in pregnancy innate immune (inflammatory) responses are activated. Increased levels of interleukin (IL)-2, 12 and interferon -  (INF) have been reported to be associated with embryonal resorption and abortion. Cytokine network at the interface is a unique. Pleiotropy and redundancy of IL-2 and IL-15 at this place is of great physiological significance. These cytokines together with IL-12 and IL-18 regulate cytolytic machinery (perforin expression) of both decidual cytotoxic T lymphocytes (CTL) and NK (dNK) cells which are predominant lymphocyte population at the interface. The pregnant uterus harbors the highest concentration of perforin known to occur in any physiological or pathological condition. This cytolytic molecule might therefore subserve an immune surveillance function in protecting both mother and fetus.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA