Naslov
Pyrazole nucleus fused tri-substituted imidazole derivatives as antioxidant and antibacterial agents

Autori
Brahmbhatt, Harshad ; Molnar, Maja ; Pavić, Valentina

Izvornik
Karbala International Journal of Modern Science (2405-609X) 4 (2018), 2; 200-206

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
benzil ; substituted 1H-pyrazole-4-carbaldehyde ; Radziszewski reaction ; antibacterial activity ; antioxidant activity

Sažetak
A novel series of tri-substituted imidazole derivatives were synthesized according to well- known Radziszewski reaction. Desired molecules were obtained in reaction of benzil, ammonium acetate and different derivatives of 1H- pyrazole-4-carbaldehyde. Structures of synthesized entities were confirmed with the support of modern techniques like elemental analysis (CHN) and spectral analysis (FTIR, 1H- and 13C-NMR and LC–MS). All compounds were screened for their biological potency like: antibacterial activity using serial broth dilution method and antioxidant activity using DPPH method. Antimicrobial activity was performed against Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). The title compounds showed moderate to excellent antimicrobial and antioxidant potency against different bacterial strains and DPPH radical.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija

POVEZANOST RADA