Pregled bibliografske jedinice broj: 916945
DNA–Protein Crosslink Proteolysis Repair
DNA–Protein Crosslink Proteolysis Repair // Trends in biochemical sciences, 42 (2017), 6; 483-495 doi:10.1016/j.tibs.2017.03.005 (međunarodna recenzija, pregledni rad, stručni)
CROSBI ID: 916945 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
DNA–Protein Crosslink Proteolysis Repair
Autori
Vaz, Bruno ; Popović, Marta ; Ramadan, Kristijan
Izvornik
Trends in biochemical sciences (0968-0004) 42
(2017), 6;
483-495
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni
Ključne riječi
aging, cancer, DNA–protein crosslink, DNA–protein crosslink proteolysis repair, DNA replication, genome stability, SPARTAN (DVC1) protease, Wss1 protease
Sažetak
Proteins that are covalently bound to DNA constitute a specific type of DNA lesion known as DNA–protein crosslinks (DPCs). DPCs represent physical obstacles to the progression of DNA replication. If not repaired, DPCs cause stalling of DNA replication forks that consequently leads to DNA double-strand breaks, the most cytotoxic DNA lesion. Although DPCs are common DNA lesions, the mechanism of DPC repair was unclear until now. Recent work unveiled that DPC repair is orchestrated by proteolysis performed by two distinct metalloproteases, SPARTAN in metazoans and Wss1 in yeast. This review summarizes recent discoveries on two proteases in DNA replication-coupled DPC repair and establishes DPC proteolysis repair as a separate DNA repair pathway for genome stability and protection from accelerated aging and cancer.
Izvorni jezik
Engleski
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
