Naslov
Cytolytic mechanisms at the maternal-fetal interface (Lectures on "Recent advances in immunology"), pozvano predavanje na: European Meeting of Immunology and Reproduction, Rome, October 28-29, 1999.
(Cytolytic mechanisms at the maternal-fetal interface" (Lectures on "Recent advances in immunology"), Invited Lecture, European Meeting of Immunology and Reproduction, Rome, October 28-29, 1999.)

Autori
Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Final program and abstract book / Dondero, Franco ; Lenzi, Andrea - Rim : University of Rome, 1999, 80-80

Skup
European Meeting of Immunology and Reproduction and joint Meeting 5th Congress of the Alps Adria Society of Immunology of Reproduction

Mjesto i datum
Rim, Italija, 28.10.1999. - 29.10.1999

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Maternal-fetal interface; Fas-Fas Ligand; Decidual NK cells; IL-15

Sažetak
Cytotoxic T lymphocytes (CTL) and Natural killer (NK) cells, mediators in acute cytolytic pathway, are present at the maternal-fetal interface. At the molecular level acute cytotoxicity is mediated by Perforin and Granzymes and Fas-Fas Ligand (FasL) pathways. In the absence of both cytotoxic pathways (double deficiency in mice, CDD) CTL and NK cells are unable to remove macrophages from decidua resulting in untrammeled T lymphocyte activation, autoimmune destruction and infertility. Female mice homozygous for FasL defect but heterozygous for Perforin locus reproduce normally, which supports hypothesis that Perforin in decidual lymphocytes contributes to the homeostasis of pregnant state including maintenace of Th2 phenotype, by eliminating antigen presenting cells that are biased towards Th1 production. Decidual NK (dNK) cells are predominant lymphocyte population at the maternal-fetal interface in humans and they are fully equipped with Perforin (bright). The level of Perforin expression at so high levels: 1) decidual macrophages and stromal cells, 2) hormones, and 3) cytokines. Critical role is ascribed to IL-15 at the interface. IL-15 maximally primes cytolitic armamentarium (upregulation of Perforin expression) for function (killing) during pregnancy, but simultaneously downregulates cytotoxicity, which prevents accidental activation under physiological circumstances. However, in pathological conditions (Th1 cytokines predominance) this pathway can be triggered.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA