Pregled bibliografske jedinice broj: 916101
In silico testing of the toxicity for some anticancer herbal compounds
In silico testing of the toxicity for some anticancer herbal compounds // Proceedings of International Conference on Innovative Technologies / Pepelnjak Tomaž ; Car Zlatan ; Kudláček Jan (ur.).
Jaromer: Tehnički fakultet Sveučilišta u Rijeci, 2017. str. 217-220 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
CROSBI ID: 916101 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
In silico testing of the toxicity for some anticancer herbal compounds
Autori
Tomić, Draško ; Puškarić, Miroslav ; Car, Zlatan
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
Proceedings of International Conference on Innovative Technologies
/ Pepelnjak Tomaž ; Car Zlatan ; Kudláček Jan - Jaromer : Tehnički fakultet Sveučilišta u Rijeci, 2017, 217-220
Skup
IN-TECH 2017 International Conference on Innovative Technologies
Mjesto i datum
Ljubljana, Slovenija, 11.09.2017. - 13.09.2017
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
anticancer herval compounds ; in silico testing of toxicity ; dose dependent level of toxicity ; successive cumulation of drug in tissues
Sažetak
Herbal based anticancer drugs are known for their relative low toxicity compared to standard chemoterapeutics. Besides, the developing of cancer resistance to herbal based drug is less frequent, due to the complex drug structure. However, as each drug, these drugs can also express the considerable and in some cases even fatal dose dependent level of toxicity, when applied in to high doses. Another cause of toxicity can be a too long period of therapy, due to the successive cumulation of a drug in the tissues. Besides, the toxicity can be expressed as genotoxicity, cardiotoxicity, dermal toxicity, hepatotoxicity, nephrotoxicity and receptor- mediated toxicity, or any combination of them. Therefore, and especially in cases when standard chemoterapeutics are no choice, the application of herbal based anticancer drugs is the only choice. As clinical trials for these class of drugs are relative rare, their toxicity is mostly unknown. For this, we performed in silico testing for several herbal anticancer compounds, and where available, compared the results with toxicity data gathered from in vivo experiments. Our results show in silico testing of toxicity of anticancer herbal compounds is of the outmost importance in cased when the standard therapy fails, in vivo experimental data are missing or incomplete, and the quick alternative therapy is the only way to aleviate cancer related clinical simptoms.
Izvorni jezik
Engleski
Znanstvena područja
Računarstvo, Biotehnologija, Informacijske i komunikacijske znanosti
POVEZANOST RADA
Ustanove:
Tehnički fakultet, Rijeka,
Fakultet informatike i digitalnih tehnologija, Rijeka,
Sveučilište u Rijeci - Odjel za biotehnologiju
