Naslov
Prediction of particle size distribution of dronedarone hydrochloride in spiral jet mill using design of experiments

Autori
Kordić, Šimo ; Matijašić, Gordana ; Gretić, Matija

Izvornik
Chemical engineering communications (0098-6445) 205 (2018), 2; 197-206

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
design of experiments ; dronedarone hydrochloride ; energy consumption ; kinetic energy ; micronization ; spiral jet mill

Sažetak
In pharmaceutical industry, micronization is used to achieve solubility enhancement through the increase in specific surface area, and finally improving the dissolution rate of the drug. Industrial application of micronization is mostly based on experience and trial and error method. This research deals with the micronization of dronedarone hydrochloride and the path for evaluation of characteristics of micronized drug. Micronization was performed in laboratory spiral jet mill and the samples were analyzed to determine particle size distribution, span of distribution, sphericity, shape, and specific surface area. Results were analyzed using analysis of variance and in terms of specific energy consumption. Paths for evaluation of particle size and span of distribution were proposed and good correlation between experimental and model results was achieved.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo

POVEZANOST RADA