Pregled bibliografske jedinice broj: 911215
Synthesis and Antitumor Activities of Novel Pyrimidine Derivatives of 2, 3-O, O-Dibenzyl-6-deoxy-L-ascorbic Acid and 4, 5-Didehydro-5, 6-dideoxy-L-ascorbic Acid
Synthesis and Antitumor Activities of Novel Pyrimidine Derivatives of 2, 3-O, O-Dibenzyl-6-deoxy-L-ascorbic Acid and 4, 5-Didehydro-5, 6-dideoxy-L-ascorbic Acid // ChemInform, 32 (2001), 13; 13-144, 1 doi:10.1002/chin.200113144 (podatak o recenziji nije dostupan, prikaz, znanstveni)
CROSBI ID: 911215 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis and Antitumor Activities of Novel Pyrimidine Derivatives of 2, 3-O, O-Dibenzyl-6-deoxy-L-ascorbic Acid and 4, 5-Didehydro-5, 6-dideoxy-L-ascorbic Acid
Autori
Raić-Malić, Silvana ; Svedružić, Draženka ; Gazivoda, Tatjana ; Marunović, Andreja ; Hergold-Brundić, Antonija ; Nagl, Ante ; Balzarini, Jan ; De Clercq, Erik ; Mintas, Mladen
Izvornik
ChemInform (0931-7597) 32
(2001), 13;
13-144, 1
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni
Ključne riječi
pyrimidine, ascorbic acid, NMR
Sažetak
SAR studies of title derivatives (I) and (II), concerning their antiviral and antitumor activity, reveal that none of the compounds shows appreciable antiviral activity, but that compound (IIb) exhibits significant antitumor cell activity, particularly against murine leukemia L1210/0, murine mammary carcinoma FM3A/0, and, to a lesser extent, human T-lymphocyte cells Molt4/C8 and CEM/0 cell lines. The Z-configuration of the C-4’–C-5’ double bond and the position of the benzyl group in the lactone ring of derivative (IId) are determined by 1H and 13C NMR, COSY, ROESY, and HMBC spectroscopic analyses.
Izvorni jezik
Engleski
POVEZANOST RADA
