Naslov
Translational models for vascular cognitive impairment: a review including larger species.

Autori
Hainsworth, Atticus H. ; Allan, Stuart M., ; Boltze, Johannes ; Cunningham, Catriona ; Farris, Chad ; Head, Elizabeth ; Ihara, Masafumi ; Isaacs, Jeremy D. ; Kalaria, Raj N. ; Lesnik Oberstein, Saskia A.M.J. ; Moss, Mark B. ; Nitzsche, Björn ; Rosenberg, Gary A ; Rutten, Julie W. ; Salkovic- Petrisic, Melita ; Troen ; Aron M

Izvornik
Bmc medicine (1741-7015) 15 (2017), 1; 16, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Experimental models ; In vivo models ; Translational models ; VCID ; Vascular cognitive impairment ; Vascular dementia

Sažetak
BACKGROUND: Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited. METHODS: We included models that mimic VCI-related brain lesions (white matter hypoperfusion injury, focal ischaemia, cerebral amyloid angiopathy) or reproduce VCI risk factors (old age, hypertension, hyperhomocysteinemia, high- salt/high-fat diet) or reproduce genetic causes of VCI (CADASIL-causing Notch3 mutations). CONCLUSIONS: We concluded that (1) translational models may reflect a VCI-relevant pathological process, while not fully replicating a human disease spectrum ; (2) rodent models of VCI are limited by paucity of white matter ; and (3) further translational models, and improved cognitive testing instruments, are required.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA