Naslov
Effective anti-adhesives of uropathogenic Escherichia coli

Autori
Ribić, Rosana ; Meštović, Tomislav ; Neuberg, Marijana ; Kozina, Goran

Izvornik
Acta pharmaceutica (1330-0075) 68 (2018), 1; 1-18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
urinary tract infections, type I fimbriae, P pili, mannosides, cranberry, polyphenols

Sažetak
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) represent one of the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents, an enormous financial burden is placed on healthcare systems around the world. Therefore, novel approaches for the prevention and treatment of UTIs are needed. Although UPEC may harbour a plethora of virulence factors, type I fimbriae and P pili are two of the most studied adhesive organelles, since the attachment to host cells in the urinary tract is a crucial step towards infection. A design of receptor analogs which competitively bind to UPEC surface adhesins placed at the top of pilin organelles led to the development of anti-adhesive drugs that are increasingly recognized as important and promising alternatives to antibiotic treatment of UTIs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA