Naslov
Requirement of circadian genes for cocaine sensitization in Drosophila

Autori
Andretić, Rozi ; Chaney Sarah ; Hirsh Jay

Izvornik
Science (0036-8075) 285 (1999), 5430; 1066-1068

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
clock gene ; behavioral sensitization ; period protein ; double-time ; melanogaster ; addiction ; mutants ; rhythms ; transcription ; responses

Sažetak
The circadian clock consists of a feedback loop in which clock genes are rhythmically expressed, giving rise to cycling Levels of RNA and proteins. Four of the five circadian genes identified to date influence responsiveness to free-base cocaine in the fruit fly, Drosophila melanogaster, Sensitization to repeated cocaine exposures, a phenomenon also seen in humans and animal models and associated with enhanced drug craving, is eliminated in flies mutant for period, clock, cycle, and doubletime, but not in flies lacking the gene timeless. Flies that do not sensitize owing to lack of these genes do not show the induction of tyrosine decarboxylase normally seen after cocaine exposure. These findings indicate unexpected roles for these genes in regulating cocaine sensitization and indicate that they function as regulators of tyrosine decarboxylase.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA