Naslov
Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova
(Significance of drug metabolism in onset of idiosyncratic reactions)

Autori
Antolić, Andrea ; Bojić, Mirza

Izvornik
Farmaceutski glasnik : glasilo Hrvatskog farmaceutskog društva (0014-8202) 73 (2017); 1-16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Idiosinkratske reakcije, metabolizam
(Idiosyncratic reactions, metabolism)

Sažetak
Idiosyncratic drug reactions (IDRs) are rare, dose independent adverse drug reactions. Although non-predictable they are not idiopathic and their causes can be rationalized. Drugs susceptible to IDRs usually undergo extensive metabolism. Most common cause of IDRs are reactive metabolites generated through drug biotransformation. In this paper an overview of drugs susceptible to IDRs is given, based on eff ected organs. IDRs on skin are illustrated with metabolism phenytoin and nevirapine. Hematological IDRs are exemplifi ed with clozapine and felbamate. Hepatotoxicity related to IDRs is explained on valproic acid, troglitazone and ximelagatran. Among strategies on how to reduce occurrence of IDRs include avoidance of specifi c functional groups (toxicophores) present a viable option.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA