Naslov
Influence of KIR2DS4 gene on related hematopoietic stem cell transplantation outcome

Autori
Burek Kamenaric, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
11th East-West Immunogenetics Conference 2017

Mjesto i datum
Olomouc, Češka Republika, 09.03.2017. - 11.03.2017

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
KIR2DS4, related HSCT

Sažetak
Killer cell immunoglobulin-like receptors (KIR) are a family of genetically very polymorphic inhibitory/activating receptors expressed on NK cells. Interactions between KIR receptors of donor cells and corresponding HLA class I molecules on the target recipient cells have been shown to modify hematopoietic stem cell transplantation (HSCT) outcome. The aim of this research was to determine the KIR2DS4 allele variants distribution among 55 patients with hematological malignancy who underwent HSCT from matched related donor, and to evaluate KIR2DS4 alleles’ impact on HSCT outcome. KIR genotyping was performed by the PCR-SSOP method that allows determining the presence or absence of KIR genes and providing information about KIR2DS4 allele variants. The KIR gene frequency analysis showed a significantly higher incidence of full-length KIR2DS4 alleles among patients (P<0.0001). The impact of KIR2DS4 alleles on transplantation outcomes revealed that donors’ full-length KIR2DS4 alleles are associated with lower overall survival rates (P=0.016) and higher relapse incidence (P=0.006). Our findings suggest that the expression of full-length KIR2DS4 alleles contributes to a worse clinical outcome after HSCT. Patients transplanted from full-length KIR2DS4 positive donors are at a higher risk of disease relapse and have a decreased chance of survival.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA