Naslov
Transcriptional Regulation during CD8 T-Cell Immune Responses

Autori
Munitic, Ivana ; Evaristo, César ; Sung, Hsueh Cheng ; Rocha, Benedita

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Memory T cells

Urednik/ci
Springer

Izdavač
Springer

Grad
Berlin

Godina
2010

Raspon stranica
11-27

ISBN
978-1-4419-6451-9

Ključne riječi
CD8 cells, T cell memory, T cell differentiation, transcriptional regulation

Sažetak
Naive CD8 T cells differentiate in response to antigen stimulation. They acquire the capacity to express multiple effector molecules and mediate effector functions that contribute to infection control. Once antigen loads are reduced they revert progressively to a less activated status and eventually reach a steady-state referred to as "memory" that is very different from that of naive cells. Indeed, these "memory" cells are "ready-to-go" populations that acquired the capacity to respond more efficiently to antigen stimulation. They modify their cell cycle machinery in order to divide faster ; they likely improve DNA repair and other cell survival mechanisms in order to survive during division and thus to generate much larger clones of effector cells ; finally, they also mediate effector functions much faster. These modifications are the consequence of changes in the expression of multiple genes, i.e., on the utilization of a new transcription program.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA